Why is Tracking all Industrial Control System Changes Critical for Pharmaceutical Manufacturers? The Coronavirus pandemic has had some effect on just about every business in the world, including industrial manufacturing. Pharmaceutical manufacturers have an extra complication in that the world is depending on them and the stakes are even higher to avoid errors and production interruptions. The increased need for certain drugs and therapies also requires that plants be more agile to meet changing demands. Adding to these challenges is the continued regulatory scrutiny on the life sciences industry and the unfortunate, but still very real risk, of cyber-attacks. Protection from Errors and Downtime Industrial control system (ICS) devices such as PLCs, HMI/SCADA systems, robots, etc. and their logic programs are vital to manufacturers in ensuring pharmaceuticals are produced consistently, reliably, and safely. They also must function exactly as intended. An inadvertent program change can result in downtime and contaminated products.